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Earle Burgess: Bipolar androgen therapy for advanced prostate cancer
Jul 24, 2024, 13:13

Earle Burgess: Bipolar androgen therapy for advanced prostate cancer

Earle Burgess, Genitourinary Medical Oncologist, Atrium Health Levine Cancer Institute, shared on LinkedIn:

“Bipolar androgen therapy (BAT) for advanced prostate cancer: I am an advocate in the appropriate patient setting based on the TRANSFORMER study.

TRANSFORMER results and protocol.
Unfortunately we don’t know in advance which patients are most likely to benefit from using BAT.

Data presented from the TRANSFORMER study at ASCO24 suggest patients whose tumors contain an androgen receptor (AR) gene alteration may be the group most likely to benefit from BAT.

TRANSFORMER: A Randomized Phase II Study Comparing Bipolar Androgen Therapy Versus Enzalutamide in Asymptomatic Men With Castration-Resistant Metastatic Prostate Cancer‘ | Journal of Clinical Oncology

Authors: Samuel R DenmeadeHao WangNeeraj AgarwalDavid C SmithMichael T SchweizerMark N SteinVasileios AssikisPrzemyslaw W TwardowskiThomas W FlaigRussell Z SzmulewitzJeffrey M HolzbeierleinRalph J HaukeGuru SonpavdeJorge A GarciaArif HussainOliver SartorShifeng MaoHarry CaoWei FuTing WangRehab AbdallahSu Jin LimVanessa BolejackChanning J PallerMichael A CarducciMark C MarkowskiMario A EisenbergerEmmanuel S Antonarakis.

Earle Burgess

Source: Earle Burgess/LinkedIn