Secondary vital enables cross species interrogation and integration of cell states
Anirban Maitra, Professor of Pathology and Translational Molecular Pathology at UT MD Anderson Cancer Center, shared a recent article by Jonathan Rub on X:
“If you conduct or use single cell RNA-sequence data from both humans and mice in your lab, this preprint releases a very useful tool called scVital.
Developed by Doron Betel (with a cameo by Tuomas Tammela) scVital enables cross species interrogation and integration of cell states, and is benchmarked for batch correction.
While cancer tissues are the obvious choice for species agnostic state integration (for example see Pancreatic Cancer mouse and human scRNA-sequence overlay below), scVital can be applied to any normal tissue for state and cell type integration across species (see supplementary data for examples).
At first look, this totally beats looking at the list of genes on overlapping Venn diagrams.”
Title: A deep-learning tool for species-agnostic integration of cancer cell states
Authors: Jonathan Rub, Jason E Chan, Carleigh Sussman, William D. Tap, Samuel Singer, Tuomas Tammela and Doron Betel
Dr. Anirban Maitra serves as Professor of Pathology and Translational Molecular Pathology at UT MD Anderson Cancer Center since August 2013, and directs the Sheikh Ahmed Pancreatic Cancer Research Center. He leads an NCI-funded laboratory dedicated to pancreatic cancer research, focusing on genetics and molecular pathology in human and mouse models. His research aims to advance early detection and interception strategies to enhance patient survival rates in pancreatic cancer.
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