Exciting insights from Nature Aging summarize the intricate relationship between aging and cancer – The Babak Lab
Maria (Masha) Babak, Head of The Babak Lab and an Assistant Professor at the City University of Hong Kong, shared a post by The Babak Lab, on LinkedIn, adding:
“Important review on the mechanistic links between aging and cancer, covering DNA damage, telomere biology, and immunosenescence. Relevant for both basic and translational research. Have a read!”
Quoting The Babak Lab‘s post:
“Scientific Wednesdays: How Time Shapes Disease
Exciting insights from Nature Aging summarize the intricate relationship between aging and cancer. This review explores how shared molecular pathways, such as genomic instability, telomere dysfunction, cellular senescence, and immune decline, drive both aging and tumorigenesis.
Key Takeaways:
1. DNA Damage and Mutations: Accumulation over time fuels both aging and cancer, with clonal expansion of mutated cells playing a dual role.
2. Telomeres: Short or damaged telomeres limit cell proliferation (anti-cancer) but can also promote genomic instability (pro-cancer).
3. Senescence: While it halts precancerous cells, the senescence-associated secretory phenotype (SASP) can create a pro-inflammatory, tumor-permissive microenvironment.
4. Immunosenescence: Aged immune systems struggle to clear senescent or malignant cells, exacerbating cancer risk.
Understanding these links opens doors for therapies targeting aging pathways to prevent or treat cancer. However, it is also important for preclinical models to better mimic aged microenvironments to improve translation.”
The complex interplay between aging and cancer
Authors: Lucrezia A. Trastus and Fabrizio d’Adda di Fagagna
aging and cancer
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