George L Kumar: Why the Blood–Brain Barrier Gets Leakier with Age
George L Kumar, Senior Director at AstraZeneca, shared on LinkedIn about recent paper by Quinn Lee et al.:
“Why the Blood–Brain Barrier Gets Leakier with Age.
Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrier.
A new Cell Reports study reveals that aging disrupts the molecular ‘glue’ holding brain blood vessels together. The researchers found that N-cadherin, a key adhesion protein, stabilizes occludin at tight junctions via the PI3Kβ–Akt3 pathway.
With age—or when N-cadherin is genetically deleted—these junctions destabilize, making the blood–brain barrier more permeable and impairing short-term memory.
Understanding this pathway opens the door to new strategies for protecting brain health and preventing age-related cognitive decline.”
Title: Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrier
Authors: Quinn Lee, Wan Ching Chan, Shuangping Zhao, Harry M. Hailemeskel, Riya Thomas, Mohsin Zafar, Fozia Mir, Peter T. Toth, Kamran Avanaki, Leon M. Tai, Jeffrey Loeb, Yulia A. Komarova
Read The Full Article at Cell Reports.
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