Breaking Down the Impact of Ionizing Radiation on Cancer
Brittney Abernathy, Journal Manager at Frontiers in Nuclear Medicine, shared a recent article by Yonwaba Mzizi on LinkedIn:
“Breaking Down the Impact of Ionizing Radiation on Cancer: From Biomarkers to Treatment.
Fascinating new research by Yonwaba Mzizi, Sipho Mdanda, Saidon Mbambar, Dr. Boitumelo Moetlhoa, Johncy Mahapane, Mike Sathekge, and Mankgopo Kgatle reveals how ionizing radiation (IR) shapes cancer development and treatment through key biomarkers.
Key Findings:
IR exposure triggers complex cellular responses, activating specific genes (MDM2, GADD45, CDKN1A) and proteins (CRP, MCP-1, SAA) that influence cancer development and treatment outcomes.
DNA damage response mechanisms, particularly through ATM/ATR pathways, play a crucial role in determining cellular fate post-radiation.
Protein biomarkers like γH2AX and VEGF serve as valuable indicators of radiation-induced damage and treatment response.
What’s particularly intriguing is how these biomarkers could revolutionize personalized radiation therapy.
Understanding the interplay between IR exposure and biomarker regulation offers promising opportunities for:
Enhanced treatment planning.
Better prediction of radiation sensitivity.
Improved patient outcomes.
More effective combination therapies.
This comprehensive review highlights the urgent need for advanced technologies like next-generation sequencing to identify novel biomarkers on a genome-wide scale.
What are your thoughts on using these biomarkers to optimize radiation therapy protocols?
How might this knowledge reshape our approach to cancer treatment?
Read the full article in Frontiers in Nuclear Medicine.”
Authors: Yonwaba Mzizi, Saidon Mbambara, Boitumelo Moetlhoa, Johncy Mahapane, Sipho Mdanda, Mike Sathekge and Mankgopo Kgatle
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