Rosandra Kaplan: How does metastasis happen?
Rosandra Kaplan, Senior Investigator Physician Scientist Pediatric Oncologist at National Cancer Institute (NCI), shared a post by John Gordon, Vice president of Scientific Affairs at Celentyx Ltd, on LinkedIn, adding:
“How does metastasis happen? The pre-metastatic niche starts in the bone seeding myeloid cells to distant sites to support disseminated tumor cells. Bone is both a metastatic site and breeding ground for distant metastases.
We provide an update on bone niche biology in the setting of cancer.”
Quoting John Gordon’s post:
“How the Bone Microenvironment shapes the pre-Metastatic Niche & Metastasis | Breaking Review by Rosandra Kaplan, MD and Co. | Online now at Nature
The bone is a frequent metastatic site, with changes in the mineralized bone and the bone marrow milieu that can also prime other sites for metastasis by educating progenitor cells to support metastatic spread.
Stromal and immune populations cooperatively maintain the organizationally complex bone niches and are dysregulated in the presence of a distant primary tumor and metastatic disease.
Interrogating the bone niches that facilitate metastatic spread using innovative technologies holds the potential to aid in preventing metastasis in and mediated by the bone.
Here, Kailey Jackett, et al review recent advances in bone niche biology and its adaptations in the context of cancer.”
How the bone microenvironment shapes the pre-metastatic niche and metastasis
Authors: Kailey N. Jackett, Alice T. Browne, Etan R. Aber, Miranda Clements and Rosandra N. Kaplan
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