The diversity of CD8+ T cell dysfunction in cancer and viral infection
Cell Stress & Immunity (CSI) Lab shared an article by Lorenzo Galluzzi, et al. on X:
“Happy to share our Nature Rev Immunol article; Result of excellent collaboration with Lorenzo Galluzzi, Adrian Liston and K Smith!
Take home message: Time to move away from narrow concept of exhausted T cells to other states!
The diversity of CD8+ T cell dysfunction in cancer and viral infection
Authors: Lorenzo Galluzzi, Kellie N. Smith, Adrian Liston, Abhishek D. Garg.
We propose novel framework to enhance our understanding of these T-cell hypofunctional states, which include tolerization, anergy, senescence, cell death, exclusion and ignorance, apart from exhaustion; with ultimate aim of improving clinical management of patients!
We discuss that enrichment of CD8 T-cell hypofunctional states and their diversity may depend on quantitative and qualitative determinants of disease development and progression, during both Infection (burden vs. duration) and cancer (antigens vs. infiltration)!
We discuss how tumour’s spatial web supports T cells or causes dysfunction/exclusion e.g., supportive perivascular or pro-immunogenic/antigenic niches and tertiary lymphoid structures vs. hypoxic cores, wound healing and myeloid, stromal or fibroblastic barriers .
We propose an uptodate summary of various CD8+ T cell trajectories occurring following treatment of T cell hot or pseudohot solid tumours with immune checkpoint inhibitors!
We propose an uptodate summary of various CD8+ T cell trajectories occurring following treatment of T cell cold or pseudocold solid tumours with immune checkpoint inhibitors!
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