Tony Cillo: Excited to share our paper on anti-PD1+anti-LAG3 therapy in melanoma

Tony Cillo, Assistant professor in the Department of Immunology at the University of Pittsburgh.

“Excited to share our paper out today in Cell with Tullia Bruno from Vignali Lab! Part of a trio of papers, we show in Melanoma, anti-PD1+anti-LAG3 therapy modifies CD8 differentiation to promote enhanced effector function.

‘Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8⁺ T cells to promote antitumor immunity‘

Authors: Anthony R. Cillo, Carly Cardello, Feng Shan, Lilit Karapetyan, Sheryl Kunning, Cindy Sander, Elizabeth Rush, Arivarasan Karunamurthy, Ryan C. Massa, Anjali Rohatgi, Creg J. Workman, John M. Kirkwood, Tullia C. Bruno, Dario A.A. Vignali.”

Source: Tony Cillo/X