Katsuaki Maehara: Removal of ICIs resistance by CAF-derived TSG-6 inhibition
Katsuaki Maehara, Cancer Biologist, shared a post on X:
“Removal of ICIs resistance by CAF-derived TSG-6 inhibition
It is well known that TAMs and CAFs in the tumor microenvironment are key players in ICIs resistance.
In this paper, we found that TSG-6 secreted by CAF in ICIs-resistant pancreatic cancer acts on CD44 of suppressive macrophages to form an immunosuppressive environment.
The administration of TSG-6 neutralizing antibody + PD-1 antibody + CTLA4 antibody in a xenograft model confirmed the following:
・Decrease in suppressive macrophages and Tregs
・Increase in CD8+ T cells
・Prolongation of survival period.
There is certainly a synergistic effect with ICIs, but with this level of drug efficacy, it is not clear if there will be a clinical introduction.
CAFs also play a role in physically blocking the infiltration of immune cells, so a drug that kills CAFs themselves may be more effective than suppressing the liquid factor of CAFs.”
Source: Katsuaki Maehara/X