Paolo Tarantino: The contribution of the payload to the molecular weight of a typical ADC
Paolo Tarantino shared on X/Twitter:
“What is the contribution of the payload to the molecular weight of a typical ADC?
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<5%
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5-10%
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10-25%
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25-50%
Answer: Only <5% of the weight of an ADC is determined by the payload.
Examples:
– T-DM1: MW 145,000 Da, of which ≈2500 Da related to the payload (738 Da X 3.5 [DAR])
– T-DXd: MW 158,000 Da, of which ≈4000 Da related to the payload (493 Da X 8 [DAR]).”
Source: Paolo Tarantino/X
Dr. Paolo Tarantino, MD researcher, holds positions at both the European Institute of Oncology in Milan, Italy, and the Dana-Farber Cancer Institute in Boston, MA, Specializing in breast cancer. Currently, Dr. Tarantino is pursuing an advanced research fellowship at Dana-Farber Cancer Institute and Harvard Medical School, concurrently working towards a PhD in clinical research at the University of Milan. His research focuses on exploring the HER2 oncoprotein, investigating the emerging HER2-low subgroup of breast tumors, and developing novel antibody-drug conjugates targeting every subtype of breast cancer. With a robust publication record exceeding 50 papers on breast cancer, he is recognized as a leading expert in the field. Dr. Tarantino’s dedication and innovative approach contribute significantly to the advancement of breast cancer treatment and research.