Wafik S. El-Deiry: Identifying specific functional roles for senescence across cell types

Wafik S. El-Deiry shared a post on X, about recent paper published in Cell:

Identifying specific functional roles for senescence across cell types.

Authors: Huan Zhao, Zixin Liu, Hui Chen, Maoying Han, Mingjun Zhang, Kuo Liu, Hengwei Jin, Xiuxiu Liu, Mengyang Shi, Wenjuan Pu, Markus Werner, Michael Meister, Stefan G. Kauschke, Ruilin Sun, Jinjin Wang, Ruling Shen, Qing-Dong Wang, Xin Ma, Jan S. Tchorz, Bin Zhou.

”Identifying specific functional roles for senescence across cell types.

‘Highlights:

• Intersectional genetics enables tracing, ablation, and manipulation of defined p16Ink4a+ cell types.
• Ablation of p16Ink4a+ macrophages ameliorates liver fibrosis.
• p16Ink4a+ endothelial cells play a reparative role in liver injury.
• Reprogramming of p16Ink4a+ endothelial cells ameliorates liver fibrosis.”’

Source: Wafik S. El-Deiry/X

Wafik S. El-Deiry, MD, PhD, FACP, FRSM, is the Associate Dean for Oncologic Sciences at the Warren Alpert Medical School and Director of the Legorreta Cancer Center at Brown University and Director of the Joint Program in Cancer Biology at Brown University and affiliated hospitals. He is the Editor in Chief at Oncotarget. Dr. El-Deiry discovered p21(WAF1) as a p53 target gene, cell cycle inhibitor, and tumor suppressor that explained the mammalian cell stress response. Dr. El-Deiry’s research is focused on mechanisms of therapy resistance with major efforts in drug discovery and development.