Denis Wirtz: Migrating monocytes in TME

Denis Wirtz, Vice Provost of Research at Johns Hopkins University, shared on X:

“Macrophages are terrible at migrating. In contrast, their precursor cells – monocytes – are highly motile.

Monocytes exploit interleukin 6 (IL-6) secreted by cancer cells and themselves to migrate fast and promote cancer cell proliferation. More here.”

High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

Autors: Wenxuan Du, Bryan Zhou, André Forjaz, Sarah M. Shin, Fan Wu, Ashleigh J. Crawford, Praful R. Nair, Adrian C. Johnston, Hoku West-Foyle, Ashley Tang, Dongjoo Kim, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu, Jude M. Phillip, Won Jin Ho, David E. Sanin, Denis Wirtz

Source: Denis Wirtz/X