Maria Natalia Gandur Quiroga: New Insights on Bladder Cancer Invasion
Maria Natalia Gandur Quiroga shared on X/Twitter:
“New Insights on Bladder Cancer Invasion.
Unraveling a hidden player in lympho-vascular invasion in bladder cancer.
- Researchers uncover how cancer-associated fibroblasts (CAFs) facilitate tumor spread through lymphatic systems in bladder cancer, offering new treatment targets.
- Key Findings:
- Specific CAFs reprogram lymphatic endothelial cells, making vessels more susceptible to invasion.
- These CAFs also remodel the extracellular matrix, aiding cancer cell migration into lymphatic vessels.
- Methods and Results:
- Single-cell mRNA sequencing identified a CAF subset crucial for lymphatic invasion.
- Mouse models confirmed that eliminating these CAFs reduces lymphovascular invasion and lymph node metastasis.
- Combined treatment with neutralizing antibodies against key CAF markers significantly cut down tumor invasion and spread.
- Implications:
- Identifying ITGA11 and CHI3L1 as potential therapeutic targets.
- Raises questions about the impact on anti-tumor immunity and the timing of treatment for it to be effective.
- Future Directions:
- Need for studies on the interaction between CAFs and immune responses, especially concerning BCG bladder treatments.
- Understanding the generation of these CAFs could lead to preventative strategies for aggressive bladder cancer.”
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Source: Maria Natalia Gandur Quiroga/X
Maria Natalia Gandur Quiroga is a Medical Oncologist and Chief of the Division of Genitourinary Medical Oncology at the Instituto de Oncología Ángel H. Roffo in Buenos Aires, Argentina. She is a Professor of Medicine at the University of Buenos Aires at the Oncologists Post Graduates Studies. Her research focuses on clinical trials with aims to improve the treatment of patients with urologic tumors. She is an active member of the European Association for Cancer Research, Argentinian Medical Association and American Society of Clinical Oncology.