Chromatin plasticity in the brain

Wafik S. El-Deiry shared on X:

“Learning about chromatin plasticity in the brain.

Chromatin plasticity predetermines neuronal eligibility for memory trace formation.

‘learning-activated neurons were enriched for hyperacetylated histones, an abundant epigenetic modification in the brain’

It is clear to me that memory enhancement is an area of interest for human beings in general including in societies with aging populations. One would be interested in models where memory can be influenced by diet, natural products, therapeutics people are exposed to or new therapeutics to enhance memory.”

Chromatin plasticity predetermines neuronal eligibility for memory trace formation

Authors: Giulia Santoni, Simone Astori, Marion Leleu, Liliane Glauser, Simon A. Zamora, Myriam Schioppa, Isabella Tarulli, Carmen Sandi and Johannes Gräff.

Source: Wafik S. El-Deiry/X

Wafik El-Deiry, MD, PhD, FACP, FRSM, is the Associate Dean for Oncologic Sciences at the Warren Alpert Medical School and Director of the Legorreta Cancer Center at Brown University and Director of the Joint Program in Cancer Biology at Brown University and affiliated hospitals.

He is the Editor in Chief at Oncotarget. Dr. El-Deiry discovered p21(WAF1) as a p53 target gene, cell cycle inhibitor, and tumor suppressor that explained the mammalian cell stress response. Dr. El-Deiry’s research is focused on mechanisms of therapy resistance with major efforts in drug discovery and development.