Insights from KCRS24 by Neeraj Agarwal
Kidney Cancer Research Summit or the KCRS24 was a conference held on 11th-12th July in Boston focused on basic science research, translational research, and clinical research in kidney cancer.
Neeraj Agarwal, Presidential Endowed Chair of Cancer Research at the Huntsman Cancer Institute, shared some highlights from the KCRS24 conference.
Novel immunotherapy treatment of mRCC:
Another wonderful talk by David Braun on novel immunotherapy treatment of mRCC. Novel ICIs, cytokines, vaccines, and microbiome modulation.
Highlights the microbiome work by Nazli Dizman and Sumanta K. Pal.
Novel (non-IO) treatments in mRCC:
One of the most comprehensive talks of the day in the KCRS24 by Rana McKay.
Novel (non-IO) treatments in mRCC – belzutifan combos, zanzalintinib, and novel strategies. Highlighting studies by Toni Choueiri and Sumanta K. Pal.
1st-line therapy of mRCC kidney cancer:
Fantastic talk by Tom Powles on 1st-line therapy of mRCC kidney cancer:
- We have reached a plateau,
- No data after adjuvant pembro
- Ipi/Nivo is applicable in favorable risk patients D
- Do not pursue intermittent TKI
Tom’s final thoughts:
Lipids and PD-1 expression on TAMs:
Obesity, cancer, and improved response to immunotherapy wonderful talk by Jeff Rathmell. Lipids suppress tumor associated macrophages (TAMs) by inducing PD-1 expression on TAMs.
Role of Pathologist in Kidney Cancer. Diagnostics and Research. Stellar talk by Rohit Mehra. Dissecting cell of origin, molecular pathways and overarching goals in RCC diagnosis.
Sarcomatoid RCC Kidney Cancer:
Sarcomatoid RCC Kidney Cancer: Diagnostic Updates and Therapeutic Implications. Comprehensive talk by Sabina Signoretti. Epigenomics, genetics and inflammed phenotype of Sarcomatoid RCC and treatment implications.
Multimodal AI-Based care of patients with RCC Kidney cancer by Dr. Christopher Weight.
Using AI to improve outcomes with existing data and personalize RCC therapy.
Prognostic and Predictive Biomarkers in Kidney Cancer. Very insightful talk by Payal Kapur. Tumor thrombus grading predicts metastasis free survival better than primary RCC grading and more.
Pathology diagnosis of RCC variants:
Surgical Pathology Toolbox and Technological Advances to Solve Kidney Cancer Problems. Excellent talk by Michelle Dunn on the pathology diagnosis of RCC variants.
Excellent job by chairs Rohit Mehra, Payal Kapur and Toni Choueiri.
Follow more KCRS24 coverage at OncoDaily.com