Caterina Sposetti: Supervised aerobic exercise in Early Breast Cancer undergoing (neo)adjuvant chemotherapy

Caterina Sposetti shared on X:

“Hot off the press article by Neil Iyengar et al. on CA: A Cancer Journal for Clinicians:

Supervised aerobic exercise (treadmill walking for 20-50 mins 3x/wk) in Early Breast Cancer undergoing (neo)adjuvant chemotherapy (ChT), significantly improves Relative Dose Intensity (RDI) for patients receiving anthracycline (n=104): 100% ChT RDI in 77% of exercise group vs. 57% usual care group (p=0.026).

In overall cohort (n=144, mean age=47y) same positive trend, but not statistically significant: 100% ChT RDI in 71% of exercise therapy group vs. 57% of usual care group (p=0.08).

No association with pCR in a subgroup receiving neoadjuvant ChT (n=49, BC subtypes quite balanced).”

Effects of exercise therapy on chemotherapy delivery and response in primary breast cancer: A secondary analysis of a randomized trial

Authors: Neil M. Iyengar, Jessica M. Scott, Jasme Lee, Jessica A. Lavery, Katherine L. Foug, Catherine P. Lee, Meghan G. Michalski, Su S. Chun, Jenna Harrison, Chaya S. Moskowitz, Lee W. Jones

Source: Caterina Sposetti/X

Caterina Sposetti is an Oncology Research Fellow at The Dana-Farber Cancer Institute and IRCCS Foundation National Cancer Institute of Milan. She completed her specialisation in medical oncology from the University of Milan.

Neil Iyengar, MD, is a medical oncologist and clinical-translational researcher at Memorial Sloan Kettering Cancer Center (MSKCC). He serves as an Associate Member and Attending Physician in the Breast Medicine Service at MSKCC, is an Associate Professor of Medicine at Weill Cornell Medicine, and holds a joint research position as an Associate Attending Physician at Rockefeller University Hospital.