Bruno Giotti: Multiple gene programs and cellular subpopulations associated with patient prognosis in pleural mesothelioma
Authors: Bruno Giotti,Komal Dolasia,William Zhao,Peiwen Cai,Robert Sweeney,Elliot Merritt,Evgeny Kiner,Grace S. Kim,Atharva Bhagwat,Thinh Nguyen,Samarth Hegde,Bailey G. Fitzgerald,Sanjana Shroff,Travis Dawson,Monica Garcia-Barros,Jamshid Abdul-Ghafar,Rachel Chen,Sacha Gnjatic,Alan Soto,Rachel Brody,Seunghee Kim-Schulze,Zhihong Chen,Kristin G. Beaumont,Miriam Merad,Raja M. Flores,Robert P. Sebra, Amir Horowitz, Thomas U. Marron, Anna Tocheva, Andrea Wolf, Alexander M. Tsankov. .
“Our study on pleural mesothelioma (PM) using scRNA-seq is finally out in Cancer Discovery!
We dissect the tumor microenvironment of PM subtypes uncovering multiple gene programs and cellular subpopulations associated with patient prognosis. Among these, we find a PLVAP+ fetal endothelial cell subpopulation enriched in sarcomatoid subtypes and provide evidence toward NK cell-based therapies targeting NKG2A in epithelioid PM tumors.
Other cool findings include enrichment of chr22 deletion in epithelioid tumors, identification of germinal center T and B cells in one of the patients, and a rare population of MHCII+ CD8 T cells in sarcomatoid tumors.
We hope these data will be a valuable resource for the biomedical community to further identify biomarkers and therapeutic targets toward better care of patients with PM!
Lots of people to thank, especially Komal Dolasia, William Zhao, Peiwei Cai, and Alex Tsankov. Thanks also to our wonderful collaborators Anna Tocheva, PhD, Amir Horowitz, Thomas Marron, Robert Sebra and Miriam Merad, MD, PhD. Last but not least, deeply grateful to the patients, their families and the surgeons who made all of this possible.”