Abhishek D. Garg: TIM3+VISTA+ macrophage subset that mediates resistance to anticancer immunotherapy and chemotherapy

Discovered via our innovative reverse translational approach! We found that these macrophages enriched in neoantigen negative tumours ONLY in BOTH mouse and humans, and their signature served as a negative prognostic and predictive biomarker in cancer patients!

This brilliant work was made possible because of a series of collaborators and our lab mates, especially the lead author Isaure Vanmeerbeek! Thanks also to Jenny Sprooten, Stefan Naulaerts, Raquel Laureano, Jannes Govaerts, Louis Boon, Susan Schlenner, Sabine Tejpar, Dirk Daelemans, Massimiliano Mazzone and others!

Thanks also to all our funders, sponsers and supporters: KU Leuven, Research Foundation Flanders – FWO, FWO Research Foundation Flanders, Faculteit Geneeskunde KU Leuven Faculty of Medicine ,UZ Leuven, Leuven Cancer Institute, Stand up Against Cancer!

Thanks also to BioTuring for supporting our computational research!

‘Targeting conserved TIM3⁺VISTA⁺ tumor-associated macrophages overcomes resistance to cancer immunotherapy’ Published in Science Advances

Authors: Isaure Vanmeerbeek, Stefan Naulaerts, Jenny Sprooten, Raquel Laureano , Jannes Govaerts, Rosa Trotta, Samantha Pretto, Shikang Zhao, Sarah Trusso Cafarello, Joren Verelst, Maarten Jacquemyn, Martyna Pociupany, ouis Boon, Susan Schlenner, Sabine Tejpar, Dirk Daelemans, Massimiliano Mazzone, And Abhishek D. Garg.”