Katsuaki Maehara: Importance of Sin3a in the stable expression of Foxp3 in Tregs
Katsuaki Maehara, Director of Medical Education Colleagues, shared a post on X, about recent paper published in Frontiers in Immunology:
T-regulatory cells require Sin3a for stable expression of Foxp3.
Authors: Lanette M. Christensen, Tatiana Akimova, Liqing Wang, Rongxiang Han, Arabinda Samanta, Eros Di Giorgio, Wayne W. Hancock.
”Importance of Sin3a in the stable expression of Foxp3 in regulatory T cells (Tregs).
A potential new therapeutic target for autoimmune diseases…. Sin3a is a well-known cofactor for HDAC1/2, but its role in Tregs was unknown.
In this paper, we show that conditional knockout, of Sin3a from Foxp3+ Tregs…
- Down-regulation of Foxp3.
- Significant decrease in the number of Tregs.
- The suppressive function of residual Tregs is also decreased.
- Activation of effector T cells.
- Production of autoantibodies.
- Extensive tissue damage.
These phenotypes were observed, and lethal autoimmunity rapidly developed.
We do not know what percentage of patients with autoimmune diseases have abnormal Sin3a, but if there are such patients, it may be possible to restore Tregs with restored Sin3a by genome editing…”
Source: Katsuaki Maehara/X