Sumanta K. Pal: Interesting interplay between microbiome and HIF2 pathways

Sumanta K. Pal shared a post by Yi Zhang et al. on X, adding:

“Interesting interplay between microbiome and HIF2 pathways.

Any implications for kidney cancer, perhaps in the context of belzutifan therapy?

Could the effect of R. torques extend beyond the gut?

Food for thought (pun intended).”

Source: Sumanta K. Pal/X

A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH

Authors: Yi Zhang, Xuemei Wang, Jun Lin, Jia Liu, Kai Wang, Qixing Nie, Chuan Ye, Lulu Sun, Yanpeng Ma, Ruize Qu, Yuejian Mao, Xuguang Zhang, Hua Lu, Pengyan Xia, Dongyu Zhao, Guang Wang, Zhipeng Zhang, Wei Fu, Changtao Jiang, and Yanli Pang