Jess Scott: What is the optimal exercise dose in prostate cancer?

Oncologists shared about new trial in JAMA Oncology:

Jess Scott, Exercise oncology researcher at MSK Cancer Center, shared on X:

“What is the optimal exercise dose in prostate cancer? Team MSK Cancer Center used a digitized, decentralized platform to test 90-450 mins/wk and found ALL doses were feasible, but 225-375 mins/wk associated with tumor activity.

This was a phase 1a nonrandomized trial to identify recommended phase 2 dose (RP2D). All study procedures/training conducted remotely in patients’ homes. Based on feasibility-tumor activity ratio, 225 mins/wk selected as RP2D”

Neoadjuvant Exercise Therapy in Prostate CancerA Phase 1, Decentralized Nonrandomized Controlled Trial

Autors: Lee W. Jones, Chaya S. Moskowitz, Catherine P. Lee, Gina A. Fickera, Su S. Chun, Meghan G. Michalski, Kurtis Stoeckel, Whitney P. Underwood, Jessica A. Lavery, Umeshkumar Bhanot, Irina Linkov, Chau T. Dang, Behfar Ehdaie, Vincent P. Laudone, James A. Eastham, Anne Collins, Patricia T. Sheerin, Lydia Y. Liu, Stefan E. Eng, Paul C. Boutros,

Neil Iyengar, Oncologist at at Memorial Sloan Kettering, shared on X:

“New in JAMA Oncology: in this first of its kind phase 1 dose finding trial, 225 min/week of mod-intensity treadmill walking was identified as the recommended phase 2 dose in men with prostate cancer. Therapeutic dose range of exercise also  PSA and Ki-67.”

Source: Jess Scott/X and Neil Iyengar/X