Zach Klaassen: Biomarker analyses in aRCC from Ph 3 CLEAR trial by Toni Choueiri

Zach Klaassen, Urology Oncologist at Georgia Cancer Center, shared a post on X:

“Biomarker analyses in aRCC from Ph 3 CLEAR trial at ASCO24 by Toni Choueiri:

• Len + Pembro arm:
  – Continuous GEP sig score not associated with the best resp
  – MYC sig score: -ve associated with the best resp
  – ORR MYC-high vs -low: 66.3% vs 84.0%
• Sun arm:
  – GEP sig score assoc with the best resp (p = 0.010)
  – ORR GEP-high vs -low: 46.9% vs 28.8%
  – Angiogenesis-high vs -low: 52.1% vs 30.4%
• ORR/PFS:  with Len + Pembro vs Sun, regardless of deleterious mutation status of BAP1, VHL, PBRM1, SETD2, KDM5C.”

Source: Zach Klaassen/X