Daniele Marinelli: NRF2-driven transcription in NSCLC

Daniele Marinelli, PhD student at the Sapienza University of Rome, shared a post on X about a recent paper by Marcello Maugeri-Saccà et al. titled “Transcriptional phenocopies of deleterious KEAP1 mutations correlate with survival outcomes in lung cancer treated with immunotherapy” published in AACR Journals.

Authors: Stefano Scalera, Biagio Ricciuti, Daniele Marinelli, Marco Mazzotta, Laura Cipriani, Giulia Bon, Giulia Schiavoni, Irene Terrenato, Alessandro Di Federico, Joao V. Alessi, Maurizio Fanciulli, Ludovica Ciuffreda, Francesca De Nicola, Frauke Goeman, Giulio Caravagna, Daniele Santini, Ruggero De Maria, Federico Cappuzzo, Gennaro Ciliberto, Mariam Jamal-Hanjani, Mark M. Awad, Nicholas McGranahan, Marcello Maugeri-Saccà.

Daniele Marinelli commented on X sharing this paper:

“Our work out in Clinical Cancer Research:

NRF2-driven transcription is found in ~50% of NSCLC and is associated with worse outcomes with ICIs regardless of KEAP1 mutations and histologic subtype.”   .

Source: Daniele Marinelli/X