Denis Wirtz: The recruitment of monocytes fuel tumor growth via MAPK pathway activation
“Our work suggests that macrophages are not recruited into a tumor, but are enriched through the recruitment of monocytes. These monocytes, not the macrophages that they differentiate into, fuel tumor growth via MAPK pathway activation. We identify tumor-associated monocytes (TAMo’s) that, unlike TAMΦ’s, display a dramatically enhanced migration induced by the TME and promote cancer cell proliferation
Read about migration capability of macrophages vs. monocytes.”
High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment
Journal: The Preprint Server for Biology
Author: Wenxuan Du, Bryan Zhou, André Forjaz, Sarah M. Shin, Fan Wu, Ashleigh J. Crawford, Praful R. Nair, Adrian C. Johnston, Hoku West-Foyle, Ashley Tang, Dongjoo Kim, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu, Jude M. Phillip, Won Jin Ho, David E. Sanin, Denis Wirtz
Source: Denis Wirtz/X