Erman Akkus: May immune-inflammation stimulation by vaccines interact with MSI-H status?

Erman Akkus, Medical Oncology Fellow at Ankara University Faculty of Medicine, shared on X:

“We have performed a hypothesis-generating case control study

dMMR (MSI-H) is associated with immune infiltration-activation, so, may immune-inflammation stimulation by vaccines interact with MSI-H status?

Among non-metastatic CRC patients diagnosed during Covid pandemic:

• Patients with dMMR CRC had significantly higher mRNA-based (BNT162b2) vaccine before diagnosis.
• No difference in CoronoVac.
• dMMR-BNT162b2 group had higher CRP, sedimentation and lower lymphoctye/CRP ratio at the diagnosis.”

Source: Erman Akkus/X