Olubukola Ayodele, Consultant Medical Oncologist at Leicester Cancer Research Centre, shared on LinkedIn:

“I’m currently attending the IKCS Europe 2024 conference in the picturesque seaside town of Sitges. It’s been wonderful to connect with so many colleagues who are dedicated to treating kidney cancer.

The management of RCC has undergone a significant shift in treatment approaches, with impressive progress made in systemic therapy for advanced RCC.

In addition to relying on data from randomized clinical trials, it’s crucial to stay informed about the practices of our colleagues when it comes to sequencing treatments and managing toxicities.

As a strong proponent of common-sense oncology, I was thrilled to hear Bernard Escudier’s presentation on the need to move beyond suboptimal comparators. It’s morally unacceptable that so many randomized trials have been conducted with such inadequate controls. We must take a stand and refuse to participate in clinical trials that are not up to standard. Sunitinib and everolimus should not be used as comparators for first and second-line mRCC trials, respectively. Additionally, the primary endpoint for first-line therapy should be overall survival, not progression-free survival.

It’s crucial that we hold studies to a high standard, and that means ensuring that comparators and endpoints are appropriate. Anything less is simply not acceptable.”

Source: Olubukola Ayodele/LinkedIn

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