Robert Z. Orlowski: Nice review of tumor-intrinsic and -extrinsic resistance mechanisms to T-cell engagers

Robert Z. Orlowski, Director of Myeloma Section at MD Anderson Cancer Center, posted on X/Twitter:

“Myeloma Paper of the Day: Nice review of tumor-intrinsic (loss of target antigen, MHC class I, preventing MHC class I:TCR co-stimulatory signaling) and -extrinsic resistance mechanisms (exhausted T cells & immunosuppressive TME) to T-cell engagers.”

Read the paper.
Source: Robert Z. Orlowski/X