Emre Yekedüz: A retrospective study from Gustave Roussy
Emre Yekedüz, Associate Professor of Medical Oncology at Ankara University and Research Fellow at , made the following post on X:
“How is it safe to use steroids and immune-suppressive (IS) agents in cancer patients treated with immune checkpoint inhibitors and who experienced grade 2 or higher immune-related adverse events?
A retrospective study from Gustave Roussy:
- 184 patients treated with ICB, all experienced at least one grade ≥2 irAE.
- 107 patients were treated with steroids alone, 20 patients received steroids plus IS, 57 patients did not receive steroids or IS.
- Patients treated with only steroids had the shortest OS and PFS.
- The data suggests that the use of steroids alone may be associated with shorter survival outcomes in ICB-treated patients.
Early use of IS agents rather than high-dose steroids alone might serve better survival outcomes!!!”
Source: Emre Yekedüz/X
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