Erman Akkus: How Genetic Testing Revolutionizes Care for Young Breast Cancer Survivors and Advances in Anaplastic Thyroid Carcinoma Treatment
Erman Akkus, Medical Oncology Fellow at Ankara University, shared on X/Twitter:
“1. Second primary breast cancer among young (≤40 year) stage 0-III breast cancer survivors: a study of JAMA
At median 10 years:
2.2% for women who did not carry a germline pathogenic variant
8.9% for carriers of a pathogenic variant
PV (pathogenic variant) carriers vs non carriers sHR (sub-hazard ratio): 5.27( 1.43-19.43)
Importance of germline genetic testing in young women with breast cancer!
Source: Erman Akkus/X
2. Pembrolizumab in addition to Dabrafenib/Trametinib for BRAFV600E-mutated anaplastic thyroid carcinoma: a study by Thyroid Journal
Pembrolizumab added upfront or at progression vs dabra-trame alone
mOS: 17 vs 9 mo, p=0.03
mPFS: 11 vs 4 mo, p=0.04
If dabra-trame given as neoadjuvant (before surgery), mOS: 63 mo.”
Source: Erman Akkus/X
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