Erman Akkus, Medical Oncology Fellow at Ankara University, shared on X/Twitter:

“Biliary tract cancers- therapeutic studies at AACR24.

• 2098 / 22 – A novel GCN2 kinase activator, NXP800, demonstrates therapeutic efficacy in preclinical cell lines and PDX models.
• 2127 / 18 –Surufatinib, an oral tyrosine kinase inhibitor, enhances radiosensitivity preclinically.
• CT133 / 12 – A phase 1b study of anti-TIM3 (S095018/Sym023) in combination with anti-PD1 (Sym021) exhibited antitumor activity in patients with advanced/metastatic recurrent biliary tract cancer who had not received prior treatment with PD-1/-L1 inhibitors. ( 2 PR (5.7%), 11 SD (31.4%), 18 PD (51.4%) and 4 not evaluable. Median PFS and OS were 1.9 m and 13.4 months).
• 4536 / 12 -MRTX1719 (targets the MTAP) plus Olaparib shows synergy in cell lines.
• 4604 / 2 – Imipridones ONC201 and ONC212 exhibit anti-tumor activity in biliary tract cancers and synergy when combined with Trametinib and Olaparib in vitro.
• 5711 / 11 – Fadraciclib (CDK2/9 dual inhibitor) shows efficacy alone or in combination with Olaparib (PARP inhibitor) or JQ1 (BRD4 inhibitor), preclinically.
• 5753 / 21 – Aptamer guided, nanovesicle mediated transcriptome targeting is a promising therapeutic strategy in preclinical CCA models that may potentiate chemotherapy response.
• 933 / 1 – Single-cell inference and validation of heterogeneous drug sensitivity reveals Dacinostat may be novel therapeutic candidate.
• 4325 / 10 – CX-4945 (Silmitasertib) (a CK2 inhibitor) induces cell death in KRAS mutant cholangiocarcinoma cell lines.
• humanized monoclonal antibodies targeting claudin-1 shows efficacy preclinically.
• 7271 / 8 – Proteasome inhibitor FHND6091 shows efficacy in PTEN-deficient cholangiocarcinoma, preclinically.
• 6525 / 10 -Targeting sulfatase-2 modulates the immune response, preclinically.”

Source: Erman Akkus/X

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